Endocrine Abstracts

Aim: Serum TSH is the target value by which adequate thyroid hormone supply can easily be monitored in patients with primary hypothyroidism. It is controversial when TSH should be measured before thyroxine dose adjustments are made, 4–8 weeks are recommended. To define the time when dose adjustments of thyroxine are feasible more clearly, we looked at the time required to reach stable TSH levels.Methods: We prospectively studied a case series of pat...

Background: The exon-3 deletion in the growth hormone receptor gene (d3 GHR) leads to an enhanced GH signal transduction. Acromegalic patients with the d3 GHR genotype could be expected to have more marked clinical or biochemical manifestations for a given GH level than those with the wild (fl) type GHR. We studied acromegalic patients for clinical and/or biochemical disease recurrence after surgery in relation to GHR genotype status to assess whether d3 GHR influences the rel...